Oftavet® Solución Oftálmica is a topical antibiotic indicated for the treatment of superficial and deep ocular infections of the eye and its adnexa, including corneal ulcers infected with bacteria sensitive to the drug.

Ciprofloxacin is a fluoroquinolone with bactericidal action. Its action is based on the inhibition of bacterial DNA gyrase or topoisomerase IV (a type of topoisomerase II), thereby preventing DNA supercoiling and replication. Cell respiration and division cease, and other processes are interrupted, including membrane integrity. Ciprofloxacin has a broad spectrum of activity, being highly effective against the most commonly found ocular pathogens, both Gram-positive and Gram-negative, such as: Staphylococcus spp., Streptococcus spp., Pseudomonas aeruginosa, Pasteurella multocida, E. coli, etc. EDTA inhibits metalloproteinases by chelating Zinc and Calcium, which the enzyme requires as a cofactor and stabilizing ion, respectively. By chelating the Calcium ion, EDTA interferes with the stability of metalloproteinases and thus reduces the stimulation for the migration of polymorphonuclear leukocytes to the corneal ulcer site. EDTA also interferes with the adhesion of metalloproteinases to the polymorphonuclear cell membrane, leading the cell membrane to an inactivated state. EDTA exhibits a high rate of anti-metalloproteinase activity in vitro (99.4%).

Each 1 mL of product contains: Ciprofloxacin Hydrochloride Monohydrate.......3.49 mg (Equivalent to 0.3% Ciprofloxacin base) Anhydrous Disodium EDTA...........................2.33 mg Excipients q.s.p...................................... 1 mL

Prescription only.